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Clinical trial results for retatrutide have exceeded even the high expectations set by tirzepatide, with Phase 2 data published in the New England Journal of Medicine in 2023 demonstrating weight loss approaching 24-25% of baseline body weight over 48 weeks in some dose groups - weight reductions comparable to those achieved with bariatric surgery and substantially exceeding pharmacological obesity treatments available just a few years ago

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The most commonly reported side effects include: Mild injection site pain, redness, or swelling Nausea or gastrointestinal discomfort Fishy body odor due to trimethylamine accumulation at higher doses Increased heart rate in sensitive individuals Allergic reactions rash, itching, swelling are rare but possible in patients with hypersensitivity to L-Carnitine